People who receive Medication-Assisted Treatment must adhere closely to the instructions for using their medications, since misusing these medications can increase the risk for relapse and adverse effects. Disulfiram and oral naltrexone must be taken daily, while the extended-release injectable form of naltrexone is administered once per month. Acamprosate must be used three times per day as directed on the label. Never skip doses of medications in MAT, and never take more than directed.

Before starting MAT, inform your doctor if you are pregnant or nursing, and if you have any allergies or existing health conditions. Some people may not benefit from MAT on behalf of certain health conditions or because the medications can produce adverse effects when used with others.

Avoid driving and other activities that require you to stay alert until you’re familiar with how your body reacts to these medications, since symptoms like extreme sleepiness and slow reaction times may occur. Also, inform your doctor immediately if you’re experiencing any side effects that are interfering with your physical or mental well-being such as depression or suicidal thoughts. Your doctor will perform an evaluation to weigh the pros and cons of stopping or staying on your medication to treat alcohol use disorder. Lastly, avoid alcohol in any form, including that in mouthwash, foods, and other medications, since alcohol use will compromise your treatment and increase the risk for serious side effects and complications.